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Inmost cells, secretory proteins destined for the apical plasmamembrane have specific sorting signals that guide their sort-ing process in the TGN. Because of shortcomings and dissatisfactionwith current allopathic medical practices, the publichas become increasingly interested in CAM and isoften exposed to promoted claims of efficacy, despitelimited clinical trial evidence regarding the benefits ofCAM in prevention or treatment of CVD as well asother ailments. The Finland,Italy, and Netherlands Elderly (FINE) study also foundthat drinking more than three cups of coffee per day wasassociated with the least 10-year cognitive decline amongelderly men (van Gelder et al., 2007b) The Finland,Italy, and Netherlands Elderly (FINE) study also foundthat drinking more than three cups of coffee per day wasassociated with the least 10-year cognitive decline amongelderly men (van Gelder et al., 2007b). Statins can improve endothelialfunction and decrease inflammation and myocardial ischemia.These beneficial effects which are independent of its lipid-lowering effects are referred as its “pleiotropic” effect.